Project Title: Association studies between the presence of Delftiatsuruhantensis Anopheles mosquitoes and rhizosphere and their effect on malaria Transmission in rice paddies across Tanzania
Project Description: A symbiont bacterium Delftiatsuruhantensis has been shown to be associated with rhizosphere of the rice plants, was isolated from midguts of laboratory reared. an Stephensi mosquitoes and associated with complete refractory of these mosquitoes to plasmodium infection. This study hypothesis that the Delftiatsuruhantensisis present in the rhizosphere of rice plant in malaria endemic regions and responsible for the reduced sporozoite rates in Anopheles mosquitoes and therefore reduced risk of malaria in these areas. This study... A symbiont bacterium Delftiatsuruhantensis has been shown to be associated with rhizosphere of the rice plants, was isolated from midguts of laboratory reared. an Stephensi mosquitoes and associated with complete refractory of these mosquitoes to plasmodium infection. This study hypothesis that the Delftiatsuruhantensisis present in the rhizosphere of rice plant in malaria endemic regions and responsible for the reduced sporozoite rates in Anopheles mosquitoes and therefore reduced risk of malaria in these areas. This study will test this hypothesis by carrying out the following; 1)Estimate the portion of malaria transmission occurring in the areas located near irrigated rice cultivation from different areas in Tanzania. 2)Determine the presence of endosymbiont bacterium Delftiatsuruhantensis from irrigated rice cultivation from different areas in Tanzania. 3)Determine whether Delftiatsuruhantensis increase refractory of laboratory reared and field caught Anopheles mosquitoes to local circulating Strains of Plasmodium through experimental infections.
Principal Investigator : Brian Tarimo
Department Name :
Time frame: (2021-11-21) - (2024-11-30)
GlaxoSmithKline Investigación y Desarrollo, S.L. (Normal)
External Collaborating Partners
None added yet.